Goat Secondary Antibodies
ABclonal Technology MRPS31 Rabbit pAb
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and aid in protein synthesis within mitochondria. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit, with about 75% protein to rRNA composition, unlike prokaryotic ribosomes, which have a higher rRNA ratio. Unlike prokaryotic ribosomes, mitoribosomes lack a 5S rRNA. The proteins in mammalian mitoribosomes vary greatly across species, complicating sequence homology recognition. The 28S subunit is believed to play a key role in translation initiation. This gene encodes a 28S subunit protein, which has been linked to type 1 diabetes, though its role in the diseases etiology is not fully understood. Pseudogenes corresponding to this gene are found on chromosomes 3 and 13.
ABclonal Technology NMNAT2 Rabbit pAb
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed, this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology MPZL1 Rabbit pAb
Predicted to enable structural molecule activity. Predicted to be involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within positive regulation of cell migration. Located in cell surface and focal adhesion.
ABclonal Technology ERG Rabbit pAb
This gene encodes a member of the ETS family of transcription factors, key regulators of development, proliferation, angiogenesis, inflammation, and apoptosis. The protein is nuclear, with an ETS DNA-binding domain and a PNT domain involved in oncoprotein self-association. It is essential for platelet adhesion, vascular remodeling, and megakaryocyte maturation. The gene is implicated in chromosomal translocations producing fusion proteins in cancers, including TMPRSS2-ERG (prostate), EWS-ERG (Ewing sarcoma), and FUS-ERG (leukemia). Over two dozen transcript variants exist due to alternative promoters and splicing, though many full-length forms remain undefined.
ABclonal Technology SLC34A1 Rabbit pAb
Enables sodiumphosphate symporter activity. Involved in several processes, including phosphate ion homeostasis, phosphate ion transport, and response to lead ion. Located in several cellular components, including apical plasma membrane, mitotic spindle, and nuclear speck. Implicated in several diseases, including Fanconi syndrome (multiple), chronic kidney disease, hereditary hypophosphatemic rickets with hypercalciuria, hypophosphatemic nephrolithiasis/osteoporosis 1, and nephrolithiasis.
ABclonal Technology PSMC5 Rabbit pAb
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings of 28 subunits, with 7 alpha and 7 beta subunits in each ring. The 19S regulator contains a base with 6 ATPase and 2 non-ATPase subunits, and a lid with up to 10 non-ATPase subunits. Proteasomes are abundant in eukaryotic cells and degrade peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway. The immunoproteasome processes class I MHC peptides. This gene encodes an ATPase subunit from the triple-A ATPase family, with chaperone-like activity. Besides proteasome functions, it may also be involved in transcriptional regulation by interacting with the thyroid hormone and retinoid X receptors. Two transcript variants encoding different isoforms have been identified.
ABclonal Technology Glucocorticoid Receptor Rabbit pAb
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID15866175).
ABclonal Technology CHCHD4 Rabbit pAb
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).
ABclonal Technology Fibrillarin/U3 RNP Rabbit pAb
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
ABclonal Technology DTL Rabbit pAb
Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination, regulation of G2/M transition of mitotic cell cycle, and translesion synthesis. Located in centrosome, cytosol, and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex.
ABclonal Technology ECI1 Rabbit pAb
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described.
ABclonal Technology TNFAIP8L2 Rabbit pAb
Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be active in cytoplasm.
American Research Products Inc Anti CD200R1 OX2R Ab huDX182
Anti-Human CD200R1/OX2R Antibody (huDX182) Research Grade
CPC Scientific H-DPhe-Cys-Tyr-DTrp-Lys-Val-Cys-Trp-NH2 (trifluoroacetate salt) 0.5MG
The somatostatin analog. Re-188-RC-160 (radioisotope RheniuM-188-labeled RC-160) has been successfully used for the local/regional treatment of experimental breast cancer and other cancers.ONE-LETTER SEQUENCE: fCYwKVCW-NH2 (C2&C7 bridge)MOLECULAR FORMULA: C57H72N12O9S2MOLECULAR WEIGHT:1133.4STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [103222-11-3], SYNONYMS: RC-160, SanvarRESEARCH AREA: GastrointestinalREFERENCES: P. O. Zamora et al., Hybridoma, 16, 85 (1997)
Cayman Chemical JWH 073 2-methylnaphthyl analog, Purity: ≥98%, CAS: 1427325-61-8, 5 mg
Differs structurally from JWH 073 by having a methyl group added at the 2 position of the naphthyl moiety; intended for forensic and research purposes